NPI are protocols to be implemented with a target population, but they are merely specifications. They must be contextualized and personalized. The NPI Registry offers best practices and tips for optimal implementation. Furthermore, the NPIS recommends interdisciplinary training in health ethics for their application. The scientific society works with its partners to develop and recognize this foundational training, which could be conducted particularly in higher education institutions in collaboration with the Ministry of Health. This ethical training includes all the prerequisites of knowledge, skills, and attitudes necessary for interprofessional practice in health. Health professionals with practical experience, such as doctors, will have equivalencies.

A scientific validation model for medications has existed since the 1960s, with specific regulations recognized worldwide (e.g., FDA, EMA, ANSM). A similar procedure has recently been implemented for medical devices in Europe. However, until now, no consensual model existed for nutritional, bodily, and psychosocial health services due to confusions between approach, protocol, and technique/ingredient. A participatory, pragmatic, and multidisciplinary consensus work followed international scientific health recommendations to address this for NPI (Ninot et al., 2023).

This work took into account the specificities of NPI, health risks, the balance between internal and external validity, the justification of explanatory mechanisms, ethical considerations in health, and respect for contexts of use. The NPIS Model accelerates research through the harmonization of methodological and ethical expectations in NPI. It also enhances the identification, referencing, transferability, and implementation of NPI for the benefit of user health and safety, improving the quality of training.

Ultimately, the NPIS Model distinguishes between individualized, science-based services aimed at addressing known health issues in Western medicine and occupational practices (lifestyle, art of living, work, sociocultural activity, personal development, pursuit of happiness, spiritual practice, etc.). In this sense, the model does not impede individuals' freedom to choose a particular lifestyle. It aims to address a specific health issue for an individual or a group of people within a limited timeframe and a framework regulated by the health sector. The NPIS Model encourages innovations across all other health sectors, particularly in health organizations and early identification actions for health problems.

An alliance for NPI is essential today in response to siloed proposals from various disciplines (biology, psychology, public health), professions (medical, paramedical, educational, social), sectors (prevention, care, support for autonomy, social services, education, end-of-life care, disability), and currents (traditional or scientific medicine) at both national and supranational levels. The NPIS brings together these scattered and sometimes divided stakeholders to foster better understanding, practice, and recognition of NPI. The scientific society contributes to developing an NPI ecosystem that is often overlooked. It mobilizes hundreds of professionals and users worldwide to address the public health challenges of the 21st century that are widely recognized.

It highlights essential NPI and best practices to be delivered to the right people at the right time in their journey without criticizing other health solutions. Specifically, the NPIS enables:

• Research stakeholders to develop, evaluate, and promote NPI.
• Care, prevention, and social support professionals to enhance their skills and access best practice recommendations and implementation tools for NPI.
• Health operators to choose, organize, track, consolidate, secure, and sustain investments in NPI.
• National and supranational health agencies to improve their knowledge for designing effective strategies regarding NPI.
• Governments, non-governmental organizations, user associations, and health actor federations to establish a common language within a defined scope to create just, equitable, and sustainable policies.

After establishing a standardized evaluation model, the NPIS contributes to an interprofessional, intersectoral, and bipartisan alliance in favor of NPI. Through an annual global summit, it gathers all stakeholders in the ecosystem during the third week of October, known as the NPIS Summit. This significant event discusses the economic and regulatory structuring of the ecosystem with all parties involved. The 2024 edition will take place in a highly symbolic venue, the Cité Universitaire in Paris, a quintessential humanist space open to the world, science, and peace, created between the two world wars last century. Everyone can participate and contribute to this international dynamic aimed solely at legitimizing NPI within health system offerings without disparaging other solutions. This coalition is called the NPIS Alliance.

NPI are a field in which many amalgamations occur between scientific knowledge and opinion, due to their objective—human health—and their operational mode, which involves immaterial protocols. However, it is essential to learn to distinguish science from research amidst the multiplication of tools and information channels (Klein, 2020), particularly on the subject of NPI. The same communication channels transmit both scientific knowledge and beliefs, opinions, comments... Information of different statuses becomes intertwined. Knowledge can turn into the belief of a particular community, and vice versa.

Research, on the other hand, pertains to questions for which we do not yet have answers. These well-defined questions still have no answer. A researcher works on the subject using various methods and strategies. Research fosters doubt. Scientific societies work to advance research within a specific territory and theme.

Given that NPI are universal health protocols centered on individuals and administered by humans, an international multidisciplinary scientific society needed to be created. This has been achieved since 2021. This society is called the Non-Pharmacological Intervention Society (NPIS).

Immaterial practices of prevention and care have existed since ancient times. However, the diversification of practices, the multiplication of professions at the intersection of prevention, care, and social assistance, and the globalization of information systems have leveled these services and obscured them at a time when medicine has made significant advances in the early detection and diagnosis of health issues. The interdisciplinary and multisectoral approach of the NPIS generates a value chain, from the design of practices to their implementation, regulation, and financing.

Innovative economic model initiatives are emerging worldwide, including fee-for-service, bundled payments, social economy provisions, offers promoting sustainable development, e-health economy, human innovation bundles, and long-term economy (World Economic Forum, 2024). The NPIS Prospective Pole, led by Michel Noguès, documents these initiatives in books (Noguès, 2022; Noguès, 2024). The NPIS Forums invite all innovators to share their experiences.